On average, only about 25 percent of transferred embryos go on to result in live births of babies. Women under 35 using their own eggs for IVF have an implantation rate of about 45 percent. Women 40 to 42 years old using their own eggs have only about a 15 percent chance of implantation. Older women who use donor eggs, which are donated by younger women, have success rates with IVF that are nearly the same as those of younger women.
Egg quality is all-important to having healthy embryos, and younger eggs usually have better quality. Especially if a woman is over 37 or has higher FSH levels she may not produce enough eggs to result in a number of embryos for screening and potential implantation.
Chances are higher that IVF will fail when this happens. Your reproductive endocrinologist will evaluate what happened and may make changes to your fertility medications for the next IVF cycle. One of the major factors in IVF failure is chromosomal abnormalities in the embryo.
This is true for all human embryos, whether naturally conceived or developed in the embryology lab. These abnormalities are the reason behind most miscarriages as well as failure to implant in an IVF cycle. Studies have shown that starting in their 30s, as women age, the incidence of choromosomal abnormalities in their eggs begins to increase. PGS tests a few cells from an embryo to determine if the correct number of chromosomes are present. In addition, as we observe the embryos on a regular basis, our embryologists are able to determine the rate of cell division.
For example, an embryo that gradually reaches the 8 cell stage by day three is much more likely to do well than an embryo that has delayed fertilization and rapid growth towards the end of this time period. The IVF laboratory is a very tightly controlled environment, in which we attempt to simulate what sperm, eggs and embryos experience inside the female reproductive tract.
Specifically, we tightly control oxygen concentration, carbon dioxide concentration, and other factors such as humidity, PH, temperature and light. Even slight alterations from what embryos normally experience can lead to death of the embryos and therefore no chance for pregnancy from the resulting cycle. Our embryologists continuously keep up with the changing literature and make alterations in our laboratory as necessary, in order to continue to optimize the environment to which gametes and embryos are exposed.
In addition, they perform daily quality assessment and control procedures in order to confirm that our equipment is always functioning optimally.
The construction of the laboratory itself, which involved the placement of multiple types of filters in the ceilings of the operating room and the laboratory, was meticulously overseen in order to guarantee an optimal laboratory environment. In addition, such seemingly minor details as using only incandescent light during procedures can have profound effects on ultimate outcome.
The surgical procedures themselves, the egg retrieval and the embryo transfer, are very important to the success of an IVF cycle. Retrieving fewer eggs than expected, or even worse — failing to retrieve any eggs, can lead to an adverse outcome. In addition, during the embryo transfer procedure — one of the most important steps of the entire cycle — embryos must be placed in the correct location.
In our program, we perform a trial transfer in order to determine, in advance, the optimal location for embryo placement.
In addition, prior to transferring the embryos, your physician will take great pains to remove any cervical mucus or other cellular debris that may plug up the transfer catheter. We also pre-treat all of our patients with a smooth muscle relaxant in order to prevent contractions of the uterus.
Despite all of the challenges noted above, in vitro fertilization remains extraordinarily successful. In other words, even if a couple fails to conceive in their first two IVF cycles, their chance for success in the third cycle is still the same as it was in cycle one or two. If, however a couple fails to conceive after three cycles of in vitro fertilization, their chance for a successful conception in another IVF cycle diminishes drastically.
At that point in time, they should consider other options such as seeking treatment at another facility, donor gametes or other alternatives. Many patients are referred to TFC following unsuccessful treatment elsewhere. That fertilization must result in a healthy embryo. That embryo must implant accordingly in the uterus. Once implanted, the embryo must continue to develop. Here are some of the more common possibilities why your IVF failed. You, and your partner, should seek support before moving forward in your treatment.
Speak with Dr. Bayrak, and let him know your concerns after a failed IVF. Seek out other treatment, or testing and evaluation, under the caring and compassionate supervision of our medical, and support staff.
Image: Pexels. Your eggs were not viable: Fertility drugs are administered to create an overstimulation of the ovaries. This results in the release of many oocytes, or eggs. When the eggs are retrieved, they are put together with the sperm to facilitate fertilization. Fertilization was not successful: In some cases fertilization simply does not occur. This can be because of the quality of the eggs, or sperm.
Embryo did not implant: There are two common reasons an embryo fails to implant.
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